The Science, Studies and References behind Red Light Therapy And Infrared Light Medicine

Red Light Therapy is one of the fastest growing trends in the Wellness Industry

 

Below Are Links to Our Favorite Studies Demonstrating The Effects of Red Light and Infrared Therapy - over 100 cases providing depth and understanding as to why Light Medicine is one of the greatest discoveries in natural healing, wellness, and rejuvenation for both the mind and body.

 

  1. History - Frieman, father of LLLT

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390214/

 

  1. History, Mechanism, Dose, Mitochondrial, Anti-inflammatory

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

 

  1. History, Mechanism, Dose, Mitochondrial, Anti-inflammatory

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

 

  1. Visible Light therapy vs. Near Infrared Light therapy

https://www.mamanatural.com/near-infrared-sauna/

 

  1. History, Mechanism, Dose, Mitochondrial, Antinflammatory

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

 

Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/

 

  1. Artificial Light and Cancer - Mal Illumination

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/

 

  1. Artificial Light and Obesity

https://www.nature.com/articles/ijo2015255

https://academic.oup.com/aje/article/180/3/245/2739112

 

  1. Light at night clock and metabolism

https://academic.oup.com/edrv/article/35/4/648/2354673

 

  1. History, Mechanism, Dose, Mitochondrial, Antinflammatory

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

 

  1. Diabetic Neuropathy

https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-_MIRE

 

Hair Loss

  1. https://www.aad.org/media/stats/conditions/skin-conditions-by-the-numbers
  2. https://www.ncbi.nlm.nih.gov/pubmed/23970445

 

Wound Healing, dairy cattle, cat tongue

  1. https://www.ncbi.nlm.nih.gov/pubmed/9068161
  2. https://pdfs.semanticscholar.org/7762/57f1debd12c652310bd11d8d53cfc5052c61.pdf
  3. https://www.researchgate.net/publication/312142584_The_photobiomodulation_effect_of_higher-fluence_808- nm_laser_therapy_with_a_flattop_handpiece_on_the_wound_healing_of_the_earthworm_Dendrobaena_veneta_a_brief_report

 

  1. Wound healing LED shows significant speed of recovery with 633nm.

https://www.ncbi.nlm.nih.gov/pubmed/16581685

 

  1. Scarring

https://www.ncbi.nlm.nih.gov/pubmed/26741110

 

  1. Dermal Abrasions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/

 

Stroke

  1. https://www.ncbi.nlm.nih.gov/pubmed/27345389
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/
  3. https://www.ncbi.nlm.nih.gov/pubmed/17463313/
  4. https://www.ncbi.nlm.nih.gov/pubmed/17678491/

 

Osteoporosis

  1. https://www.ncbi.nlm.nih.gov/pubmed/28846932

 

Transcranial effect of LED

  1. https://www.researchgate.net/publication/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain

 

Brain Injury 

  1. https://www.researchgate.net/publication/229161498_Transcranial_low_level_laser_light_therapy_for_traumatic_brain_injury
  2. https://www.ncbi.nlm.nih.gov/pubmed/17439348
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203/
  4. https://www.ncbi.nlm.nih.gov/pubmed/11059663

 

Sleep

  1. https://www.ncbi.nlm.nih.gov/pubmed/12811613
  2. https://www.ncbi.nlm.nih.gov/pubmed/12811613

 

Testosterone replacement

  1. http://connection.ebscohost.com/c/articles/96971683/effects-low-level-laser-therapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

 

Headache Light therapy modulates serotonin levels and blood flow in women with headache. A preliminary study.

  1. https://www.ncbi.nlm.nih.gov/pubmed/26202374

 

Dermal Abrasions

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/

 

Tendonitis

  1. https://www.ncbi.nlm.nih.gov/pubmed/226734405

 

Fibromayalgia

  1. https://www.ncbi.nlm.nih.gov/pubmed/24801056

 

Effectiveness of low-level laser therapy on pain intensity, pressure pain threshold, and SF-MPQ indexes of women with myofascial pain. :10.11607/ofph.2032. Epub 2018 Apr 25.

 

Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Myofascial Pain: A Systematic Review and Meta-Analysis.

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/29697718

 

Acne:

  1. https://www.ncbi.nlm.nih.gov/pubmed/16468292
  2. https://www.ncbi.nlm.nih.gov/pubmed/28232927

 

Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/22615511

 

Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease.

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/

 

Depression Long term study

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556873/

 

Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety:

  1. https://www.ncbi.nlm.nih.gov/pubmed/19995444

 

Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.

  1. https://www.ncbi.nlm.nih.gov/pubmed/27267860

 

Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.

  1. https://www.ncbi.nlm.nih.gov/pubmed/27379735

 

Dementia 

Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017;35(8):432-441

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/28186867 dementia, memory, mood

General Brain Health & Cognitive Performance. 

 

Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.

  1. https://www.ncbi.nlm.nih.gov/pubmed/23200785

 

Shining light on the head: Photobiomodulation for brain disorders

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/

 

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/

Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777909/

Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light

  1. https://www.sciencedirect.com/science/article/pii/S1074742707001153

 

Improving executive function using transcranial infrared laser stimulation.

  1. https://www.ncbi.nlm.nih.gov/pubmed/26017772
  2. https://www.ncbi.nlm.nih.gov/pubmed/26535475

 

Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.

  1. https://www.ncbi.nlm.nih.gov/pubmed/27220529

 

Neurological and psychological applications of transcranial lasers and LEDs.

  1. https://www.ncbi.nlm.nih.gov/pubmed/23806754

 

Alzheimers Disease

Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease

  1. https://www.researchgate.net/publication/263742704_Low- Level_Laser_Therapy_Ameliorates_Disease_Progression_in_a_Mouse_Model_of_Alzheimer's_Disease 

 

Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.

  1. https://www.ncbi.nlm.nih.gov/pubmed/24387311

 

Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.

  1. https://www.ncbi.nlm.nih.gov/pubmed/23946409

 

Bipolar

Is bipolar disorder an inflammatory condition? The relevance of microglial activation.

  1. https://www.ncbi.nlm.nih.gov/pubmed/23196997

 

Arthritis

mice subjected to acute arthritis condition.

  1. https://www.ncbi.nlm.nih.gov/pubmed/28772237

 

Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.

  1. https://www.ncbi.nlm.nih.gov/pubmed/24028507

 

Bell's Palsy -

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322014/

 

Testosterone

  1. The effects of low level laser therapy (LLLT) on the testis in elevating serum testosterone level in rats http://connection.ebscohost.com/c/articles/96971683/effects-low-level-lasertherapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

 

Aging Skin

Regulation of Skin Collagen Metabolism In VitroUsing a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single- Blinded Study

  1. https://www.sciencedirect.com/science/article/pii/S0022202X15341749

Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

 

ORAL HEALTH

Low Level Laser Therapy: A Panacea for oral maladies

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639680/

 

NUTS AND BOLTS OF LLLT - Survey of Basically Everything treated by LLLT

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/

 

MECHANISM OF ACTION OF LLLT - dose, etc. Biphasic Dose Response in Low Level Light

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790317/ 

The role of nitric oxide in low level light therapy

  1. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy How Mitochondria absorb visible light
  2. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy

 

REVERSAL OF AGING USING RED LIGHT AND NEAR-INFRARED LIGHT THERAPY

A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.

  1. https://www.ncbi.nlm.nih.gov/pubmed/24286286
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332991/

 

Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheeks Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/24049929
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

 

ELIMINATION OF FAT

  1. Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/

 

“Overweight and obesity.” Centers for Disease Control and Prevention (2007). Available:

  1. https://www.cdc.gov/onsidty/data/ad/ult.html

 

Sene-fiorense M, Duarte FO, De aquino junior, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Sung Med. 2015;47(7):634-42

  1. https://www.ncbi.nlm.nih.gov/pubmed/26220050

 

Ger Med Sci. 2006 Jul 11:4; Doc05. Influence of water-filtered infrared-A (wiRA) on reduction of local fat and body weight by physical exercise. Mockel F, Hoffman G, Obermuller R, Drobnik W,Schmitz G.

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703221/

 

Mcrae E, Boris J. Independent evaluation of low-level laser therapy 635nm for non-invasive body contouring of the waist, hips and thighs. Lasers Surg Med. 2013;45(1):1-7.

  1. https://www.ncbi.nlm.nih.gov/pubmed/23355338

 

  1. 635nm - 660nm for Fat Loss

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225499/

 

  1. Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/

 

Health After Cancer

  1. Warburg O. Uber den Stoffweschsel der Hefe. Pp253-254
  2. Bianconi E., Piovesan A, Facchin F, et al. An estimation of the number of cells in the human body. Ann Hun Biol 2013:40(6):463-71
  3. https://www.researchgate.net/publication/306325596_Revised_Estimates_for_the_Number_of_Human_and_Bacteria_Cells_in_the_Body

 

  1. Li, Y., Park, JS., Deng, JH. Et al. Cytochrome c oxidase subunit IV is useful for assembly and respiratory function of the enzyme complex. J Bioenerg, Biomember (2006)38;283
  2. Brown GC, Borutalite V. Nitric Oxide, cytochrome c, and mitochondria. Biochem Soc. Symp. 1999:66;17-25

https://www.ncbi.nlm.nih.gov/pubmed/10989653

 

LIGHT MEDICINE AND ANIMALS

Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase.

  1. https://www.ncbi.nlm.nih.gov/pubmed/21356170

 

Inflammation in general:

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/28748217 

Veterinary Medicine and Photobiomodulation

 

  1. http://veterinarymedicine.dvm360.com/photobiomodulation-facts-and-functions-veterinary-rehab 

An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo

 

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113823/

 

EYE HEALTH AND WOUND HEALING

  1. https://www.ncbi.nlm.nih.gov/pubmed/26427443 

Photobiomodulation for the treatment of retinal diseases: a review

 

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/

 

Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age‐related macular degeneration

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/11845369
  2. https://www.ncbi.nlm.nih.gov/pubmed/16120414

 

Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy.

 

Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and diabetic rats.

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/24551842/

 

Viral Warts

  1. https://www.researchgate.net/publication/269749233_PULSED_DYE_LASER_TREATMENT_FOR_RECALCITRANT_VIRAL_WARTS_AUTO-SIMULTANEOUS_LASER_TREATMENT

 

Plantar Warts

  1. https://www.ncbi.nlm.nih.gov/pubmed/16942430?dopt=Citation

 

Herpes

  1. https://www.ncbi.nlm.nih.gov/pubmed/16780494?dopt=Citation
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/

 

Dermatitis

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/

 

Psoriasis

  1. https://www.researchgate.net/publication/320600622_A_clinical_review_of_phototherapy_for_psoriasis

 

Improved Sleep & PTSD

  1. https://www.ncbi.nlm.nih.gov/pubmed/24568233

 

Thyroid Tissue Generation

  1. https://www.ncbi.nlm.nih.gov/pubmed/22718472
  2. https://thyroidpharmacist.com/articles/lasers-thyroid-tissue-regeneration/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534372/
  4. https://www.ncbi.nlm.nih.gov/pubmed/20662037

 

Muscle Performance and Recovery Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training

 

  1. https://www.researchgate.net/publication/269412590_Effect_of_low-level_laser_therapy_on_muscle_adaptation_to_knee_extensor_eccentric_training
  2. Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light.
  3. Cleber Ferraresi et al. 2012

https://www.ncbi.nlm.nih.gov/pubmed/23626925

 

Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review. Paul A Borsa et al. 2013

 

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554033/ Verifies the benefit of LLLT in all phases of muscle recovery: 107

 

  1. https://www.unip.br/presencial/comunicacao/publicacoes/ics/edicoes/2010/03_jul-set/V28_n3_2010_p286-288.pdf

 

Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/29090398

 

Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test: A Randomized, Crossover, Double-Blind, Placebo-Controlled Clinical Study. Pinto HD et al. 2016

  1. https://www.ncbi.nlm.nih.gov/pubmed/27050245

 

Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Ferraresi C et al. 2016

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/25378263

 

Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed- Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Ferraresi C et al. 2016

 

  1. https://www.ncbi.nlm.nih.gov/pubmed/27088469

 

Diabetic Neuropathy

 

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639677/
  2. https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-

_MIRE

 

Bell's Palsy

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838725/
  2. http://www.litecure.com/wp-content/uploads/2016/09/Laser-Bells-Palsy.pdf
  3. https://www.researchgate.net/publication/271346875_Helium_neon_and_diode_laser_therapy_is_an_effective_adjunctive_therapy_for_facial_paralysis

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